Perhaps, with the next update of the NUC platform code named 'Skull Canyon', the rumored Thunderbolt 3 / USB-c connector may make things easier as some of the existing vendors who produce Thunderbolt to ethernet adapter also use common drivers like the Broadcom tg3 which have historically worked with ESXi. However, the NUC also lacks additional IO connectors like a Thunderbolt port which the Mac Mini includes and can support a Thunderbolt to Ethernet adapter. I think this is probably the only downside to the Intel NUC platform which has been similar feedback that I have seen from other vSphere home labbers who currently use or would like to use the NUC. The Intel NUC only includes a single built-in ethernet adapter which is similar to the Mac Mini.
As part of upgrading my personal vSphere home lab from an Apple Mac Mini to an Intel NUC (more on this in a future blog), I have been researching to see if there are other alternatives for adding an additional network adapter.